The science department offers a full array of classes in physical science, biology, chemistry, physics and environmental science. Regular and honors classes are offered at all levels and advanced placement classes are available for biology, physics and chemistry. The advanced placement classes provide a full class-length component of lecture and laboratory work.

The school's science fair is one of the largest in the area, and many students advance to participatein regional, state, and even national level competition. Intel and Westinghouse sponsor science talent competitions which regularly honor Baton Rouge High students.

Science is very much a hands-on activity as students build and test rockets, bridges, and protective containers, as well as do genetics research with generations of fruit flies.

Teachers Lai Cao and Fran Frost received a $1,000 ADF grant for a collaboration between chemistry and physics classes. Cao also received an ADF fellowship grant to visit outstanding science departments in high schools throughout the nation. She will be visiting schools in San Jose and Berkeley, California.

Two science competition teams, in Science Quiz Bowl and Science Olympiad, regularly rank high in the state. Last year's Quiz Bowl team placed second in the state, while the Olympiad team, which takes written tests and builds projects, finished first in regionals, first in state and 20th in the nation.